New therapeutic strategies for postoperative ileus

Postoperative ileus: strategies for reduction

Postoperative Ileus (POI) is a frequent, frustrating occurrence for patients and surgeons after abdominal surgery. Despite significant research investigating how to reduce this multi-factorial phenomenon, a single strategy has not been shown to reduce POI's significant effects on length of stay (LOS) and hospital costs. Perhaps the most significant cause of POI is the use of narcotics for analg...

Alvimopan for postoperative ileus

Purpose. The efficacy, safety, pharmacology, pharmacokinetics, drug–drug interactions, and administration of alvimopan for postoperative ileus are reviewed. Summary. Alvimopan is a selective mopioid receptor antagonist with no central nervous system activity. When orally administered after partial smallor largebowel resection in patients with primary anastomosis, alvimopan shortened the return ...

Risk factors for postoperative ileus

PURPOSE This study aimed to examine extended postoperative ileus and its risk factors in patients who have undergone abdominal surgery, and discuss the techniques of prevention and management thereof the light of related risk factors connected with our study. METHODS This prospective study involved 103 patients who had undergone abdominal surgery. The effects of age, gender, diagnosis, surgic...

Postoperative Ileus in Elective Colorectal Surgery: Management Strategies

Management of postoperative ileus.

Postoperative ileus, a temporary cessation in bowel motility, is a common and significant complication of major surgery. Consequences of postoperative ileus include increased patient discomfort, delayed time to adequate nutrition, prolonged length of stay, and increased cost to the patient and healthcare system. The traditional, multi-modal approach to the resolution of postoperative ileus incl...